HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoic Acid → HCID 70496724, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoic Acid | HCID 243 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Bis(2-oxo-3-oxazolidinyl)phosphinic chloride | HCID 152842 | — |
| Reactant | HCID 70498233 | HCID 70498233 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 70496724 | HCID 70496724 | 10% |
Reaction Steps
Benzoic acid (35 mg; 0.17 mmol), Bop-Cl (39 mg; 0.16 mmol), DIEA (0.04 mL; 0.25 mmol), and 45 (55mg, 0.26 mmol) were suspended in DMF (2 mL), and stirred overnight at room temperature. The crude reaction mixture was purified directly via HPLC to provide 52 (7 mg, 10% yield) as a solid. LC-MS (M+H=448, obsd.=448).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08569295B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-d151819271024141ad6b82b1ced3a966 |
| Source note | uspto-grants-2013_10 |