2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl → HCID 70498313, compound

Participants

Role	Name	HCID	Charge
Reactant	2-Dicyclohexylphosphino-2',4',6'-triisoprophylbiphenyl	HCID 11155794	—
Reactant	5-Chloro-1,3-benzodioxol-4-amine	HCID 11367253	—
Reactant	Sodium t-butoxide	HCID 23676156	—
Reactant	5-chloro-3-[(4-methoxyphenyl)methyl]-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-2-one	HCID 66926291	—
Catalyst	palladium(II) acetate	HCID 167845	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 70498313	HCID 70498313	35%

Reaction Conditions

Temperature	120 °C

Reaction Steps

1 (69 mg, 0.23 mmol), 5-chloro-1,3-benzodioxol-4-amine (47 mg, 0.27 mmol), Pd(OAc)2 (2.5 mg, 0.01 mmol), X-Phos (11 mg, 0.02 mmol), and NaOtBu (65 mg, 0.68 mmol) were suspended in anhydrous dioxane (2 mL), and stirred in a microwave at 120° C. for 150 min. The crude product was purified directly via HPLC to provide 101 (35% yield). LC-MS (M+H=439, obsd.=439).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08569295B2
Source dataset	uspto-grants-2013_10
ORD ID	ord-de6d3dfbaf8845ec93f6057f4fe25119
Source note	uspto-grants-2013_10