Potassium Carbonate → HCID 70497679, compound

Participants

Role	Name	HCID	Charge
Reactant	Potassium Carbonate	HCID 11430	—
Reactant	2,4-Difluorophenylboronic acid	HCID 2734334	—
Reactant	2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl	HCID 11269872	—
Reactant	5-chloro-3-[(4-methoxyphenyl)methyl]-1H,2H,3H,4H-pyrido[2,3-d]pyrimidin-2-one	HCID 66926291	—
Catalyst	palladium(II) acetate	HCID 167845	—
Solvent	1,4-Dioxane	HCID 31275	—
Product	HCID 70497679	HCID 70497679	7%

Reaction Conditions

Temperature	100 °C

Reaction Steps

1 (65 mg, 0.21 mmol), 2,4-difluorophenylboronic acid (101 mg, 0.64 mmol), Pd(OAc)2 (5 mg, 0.02 mmol), S-Phos (18 mg, 0.04 mmol), and K2CO3 (88 mg; 0.64 mmol) were suspended in dioxane (2 mL), and stirred overnight at 100° C. The crude product was purified directly via HPLC to provide 127 (7% yield). LC-MS (M+H=382, obsd.=382).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08569295B2
Source dataset	uspto-grants-2013_10
ORD ID	ord-fc35b1ff0cd047c1a8dcca7a4dceb48f
Source note	uspto-grants-2013_10