Cesium carbonate → HCID 70498648, compound

Participants

Reaction Steps

Into a 10-mL microwave vial equipped with a stir-bar was added 5-chloro-3-ethyl-3,4-dihydropyrido[2,3-d]pyrimidin-2(1H)-one (30.00 mg; 0.14 mmol), 4-[1-(4-fluorophenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]phenol (64.70 mg; 0.21 mmol) and cesium carbonate (138.55 mg; 0.43 mmol). The mixture was suspended in DMF (2.00 ml). The vial was then loaded onto the microwave reactor and run at 160° C. for 2 h. The reaction mixture was filtered through a bed of silica under reduced pressure. The crude material was purified via Biotage eluting with a gradient of 50 to 100% EtOAc in Hexanes to provide 275 as an off-white solid. LC-MS (M+H=480, obsd.=480). 1H-NMR: (DMSO-D6) δ 9.66 (s, 1H); 8.64 (d, 1H); 8.37 (d, 1H); 7.97 (m, 4H); 7.84 (d, 2H); 7.41 (t, 2H); 7.30 (d, 2H), 6.78 (d, 1H); 6.27 (d, 1H); 4.54 (s, 2H); 3.40 (q, 2H); 1.11 (t, 3H).

Provenance & Evidence