1,1,1-Trimethoxybutane → HCID 67350918, compound

HRID 1045516Notes

Reaction equation

HRID 1045516 reaction equation
FC(F)(F)C(O)=O.[NH2:8][C:9]1([C:21]([NH2:23])=[O:22])[CH2:17][C:16]2[C:11](=[CH:12][CH:13]=[C:14]([N+:18]([O-:20])=[O:19])[CH:15]=2)[CH2:10]1.CO[C:26](OC)(OC)[CH2:27][CH2:28][CH3:29]>C1(C)C=CC=CC=1>[N+:18]([C:14]1[CH:15]=[C:16]2[C:11](=[CH:12][CH:13]=1)[CH2:10][C:9]1([C:21](=[O:22])[NH:23][C:26]([CH2:27][CH2:28][CH3:29])=[N:8]1)[CH2:17]2)([O-:20])=[O:19]

Participants

4

Reactant 2

HCID 1235121,1,1-TrimethoxybutaneHCID 67376497HCID 67376497, compound2×

Product 1

HCID 67350918HCID 67350918, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A solution of (±)-2-amino-5-nitroindane-2-carboxamide, trifluoroacetate salt (described in Intermediate 3, 25.0 mg, 0.075 mmol) and 1,1,1-trimethoxybutane (0.060 mL, 0.373 mmol) in toluene (5 mL) was heated at reflux for 16 h. The reaction mixture was concentrated under reduced pressure to give the title compound. MS: m/z=274 (M+1).

Workup

  1. temperatureat reflux for 16 h
  2. concentrationThe reaction mixture was concentrated under reduced pressure

Sources & evidence

ORD record
ord-85d023d1986f40f58c9886f13042c044
Source dataset
uspto-grants-2013_10
Patent number
US08569291B2

Reaction notes

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