Thiourea → HCID 66788626, compound

HRID 1045636Notes

Reaction equation

[NH2:1][C:2]([NH2:4])=[S:3].[Cl:5][C:6]1[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([F:15])[C:7]=1[CH2:8][Br:9]>CC(=O)CC>[BrH:9].[Cl:5][C:6]1[C:13]([Cl:14])=[CH:12][CH:11]=[C:10]([F:15])[C:7]=1[CH2:8][S:3][C:2](=[NH:4])[NH2:1]

Participants

Conditions

Temperature: 100 °C

Procedure

A mixture of thiourea (1.52 g) and 2,3-dichloro-6-fluorobenzyl bromide (commercially available) (5.16 g) in 2-butanone (20 ml) was heated to 100° C. for 5 minutes in the microwave. The reaction mixture was cooled to ambient temperature and filtered. The white solid was washed with diethyl ether to give 2-(2,3-dichloro-6-fluoro-benzyl)-isothiourea hydrobromide (5.14 g). 1H-NMR (400 MHz, CD3OD): 7.61-7.65 (m, 1H), 7.22-7.27 (m, 1H), 4.64 (m, 2H) ppm.

Workup

temperatureThe reaction mixture was cooled to ambient temperature
filtrationfiltered
washThe white solid was washed with diethyl ether

Sources & evidence

ORD record: ord-f882d452e20041a4b8102aa8f7b13798
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08569301B2

Reaction notes

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