Benzylamine → HCID 57869945, compound

Participants

Reaction Steps

A solution of (S)-3-methanesulfonyloxypyrrolidine-1-carboxylic acid tert-butyl ester (16.9 g, 57 mmol) and benzylamine (18.3 g, 171 mmol) was stirred for 4 hours at 95° C. The remaining benzylamine was evaporated off under reduced pressure and the residue was purified by silica gel column chromatography (eluent; ethyl acetate) to afford (R)-3-benzylaminopyrrolidine-1-carboxylic acid tert-butyl ester (15.3 g, 97%) as pale yellow oil.

Provenance & Evidence