反应详情

温度

10 °C

A 2 L round bottom flask was charged with 2-chloro-3-hydrazinylpyrazine (440 g, 3.0 mol) and CH3COOH (500 mL). To the above was added dropwise a solution of NaNO2 (220 g, 3.2 mol) in water (200 mL) at 10° C. The resulting mixture was stirred at 10° C. for 1 h. Work-up: the resulting crystalline solid was collected by filtration, washed with EtOH (200 mL), and dried to afford 350 g (73%) of the product as a red solid.

1. filtrationthe resulting crystalline solid was collected by filtration
2. washwashed with EtOH (200 mL)
3. customdried