Water → HCID 58447008, compound

Participants

Reaction Conditions

Reaction Steps

A 100 mL round bottom flask was charged with ethyl 8-(4-(tert-butoxycarbonyl)piperazin-1-yl)-5-(thiophen-2-yl)imidazo[1,2-a]pyrazine-2-carboxylate (prepared as described in Example 61 steps 1-5, 0.80 g, 1.75 mmol), LiOH (0.22 g, 5.25 mmol), water (2 mL) and THF (30 mL). The mixture was stirred at 25° C. for 16 h. Reaction progress was monitored by LC-MS. Work-up: the solvent was evaporated. The residue was acidified with 2 N HCl. The precipitate was collected by filtration and dried, to afford 0.57 g (76%) of the product. MS m/z: 428 (M−H+).

Provenance & Evidence