tert-Butanol → HCID 58447005, compound

Participants

Reaction Conditions

Reaction Steps

A 100 mL round bottom flask was charged with 8-(4-(tert-butoxycarbonyl)piperazin-1-yl)-5-(thiophen-2-yl)imidazo[1,2-a]pyrazine-2-carboxylic acid (0.57 g, 1.3 mmol), diphenyl phosphoryl azide (0.68 g, 2.5 mmol), triethylamine (0.25 g, 2.5 mmol) and tert-butanol (20 mL). The mixture was stirred at 80° C. for 16 h. Reaction progress was monitored by LC-MS. Work-up: the solvent was evaporated. The residue was purified by flash column chromatography on silica gel with a 1:20 EtOAc/petroleum ether, to afford 0.30 g (45%) of the product. MS m/z: 501 (M+H+).

Provenance & Evidence