Nitric Acid → HCID 178526878, compound

HRID 1045763Notes

Reaction equation

HRID 1045763 reaction equation
[N:1]1[CH:6]=[CH:5][C:4]([OH:7])=[CH:3][C:2]=1[OH:8].OS(O)(=O)=O.[N+:14]([O-])([OH:16])=[O:15]>>[N+:14]([C:3]1[C:2]([OH:8])=[N:1][CH:6]=[CH:5][C:4]=1[OH:7])([O-:16])=[O:15]

Participants

4

Reactant 3

HCID 944Nitric AcidHCID 1118Sulfuric AcidHCID 178516518HCID 178516518, compound

Product 1

HCID 178526878HCID 178526878, compoundYield 90%

Procedure

A 100 mL 3-necked round bottom flask was charged with pyridine-2,4-diol (9.0 g, 81 mmol) and concentrated H2SO4 (40 mL). To the above solution was added dropwise fuming HNO3 (40 mL) at 0° C. Work-up: the mixture was poured onto crushed ice and chilled in freezer. The resulting precipitate was collected by filtration, washed with cold water and dried in vacuo, to afford 11.4 g (90%) of the product as a colorless solid.

Workup

  1. additionthe mixture was poured
  2. customonto crushed ice
  3. temperaturechilled in freezer
  4. filtrationThe resulting precipitate was collected by filtration
  5. washwashed with cold water
  6. customdried in vacuo

Sources & evidence

ORD record
ord-a6d259ffcc764859bf2b1e628ba9fde5
Source dataset
uspto-grants-2013_10
Patent number
US08569300B2

Reaction notes

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