Bromine → HCID 178526883, compound

HRID 1045764Notes

Reaction equation

HRID 1045764 reaction equation
[N+:1]([C:4]1[C:5]([OH:11])=[N:6][CH:7]=[CH:8][C:9]=1[OH:10])([O-:3])=[O:2].[Br:12]Br>C(O)(=O)C>[Br:12][C:8]1[C:9]([OH:10])=[C:4]([N+:1]([O-:3])=[O:2])[C:5]([OH:11])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 178526878HCID 178526878, compound

Product 1

HCID 178526883HCID 178526883, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Conditions

Temperature
70 °C

Procedure

A 100 mL 3-necked round bottom flask was charged with 3-nitropyridine-2,4-diol (3.5 g, 22 mmol), bromine (1.15 mL) and acetic acid (30 mL). The resulting mixture was heated at 70° C. for 15 minutes. Work-up: the mixture was poured onto crushed ice and chilled in freezer. The resulting precipitate was collected by filtration, washed with cold water and dried in vacuo, to afford 3.7 g (80%) of the product as a colorless solid.

Workup

  1. additionWork-up: the mixture was poured
  2. customonto crushed ice
  3. temperaturechilled in freezer
  4. filtrationThe resulting precipitate was collected by filtration
  5. washwashed with cold water
  6. customdried in vacuo

Sources & evidence

ORD record
ord-e6b00cb45599483887f342bd5dd8a660
Source dataset
uspto-grants-2013_10
Patent number
US08569300B2

Reaction notes

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