反应详情

温度

70 °C

A 100 mL 3-necked round bottom flask was charged with 3-nitropyridine-2,4-diol (3.5 g, 22 mmol), bromine (1.15 mL) and acetic acid (30 mL). The resulting mixture was heated at 70° C. for 15 minutes. Work-up: the mixture was poured onto crushed ice and chilled in freezer. The resulting precipitate was collected by filtration, washed with cold water and dried in vacuo, to afford 3.7 g (80%) of the product as a colorless solid.

1. additionWork-up: the mixture was poured
2. customonto crushed ice
3. temperaturechilled in freezer
4. filtrationThe resulting precipitate was collected by filtration
5. washwashed with cold water
6. customdried in vacuo