benzyl (2S)-2-(4,4,4-trifluorobutanoylamino)propanoate → (2S)-2-(4,4,4-Trifluorobutanoylamino)propanoic acid

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Reaction Steps

Add palladium/carbon (5%, 1.76 g, 0.8 mmol) in one portion to a solution of benzyl (2S)-2-(4,4,4-trifluorobutanoylamino)propanoate (8.80 g, 29 mmol) in methanol (88 mL) at ambient temperature. Degas the mixture (vacuum/nitrogen), fill with hydrogen (one atmosphere) and stir under hydrogen (29 mmol) for 5 hours. Filter through Celite®, rinse filter cake with methanol and concentrate the filtrate to obtain the title compound as a white solid (6.11 g, 28.7 mmol, 99%). MS (m/z): 214 (M+1); [α]Na25=−24.7° (c=5.0, methanol).

Provenance & Evidence