Water → HCID 86685837, compound

Participants

Reaction Steps

Methyl (3S,4R)-4-(2,4-difluorophenyl)pyrrolidine-3-carboxylate hydrochloride (prepared according to Young, J. R. et. al. Bioorganic and Medicinal Chemistry Letters 2007, 17, 5310-5315; 100 mg, 0.360 mmol), 2,6-dichloropyridine (107 mg, 0.720 mmol) and N,N-diisopropyl-N-ethylamine (0.189 ml, 1.080 mmol) in NMP (2.0 ml) was heated by microwave (150° C., 30 min). The mixture was cooled to rt, poured into water and extracted with MTBE. Purification on SiO2 (0 to 30% EtOAc, hexanes) afforded the title compound. HPLC/MS: 353.1/354.9 (M+1); Rt=1.22 min (LC2).

Provenance & Evidence