反应详情

1,3-Dimethyl-1H-pyrazol-4-amine and 2-(2,5-dichloropyridin-4-ylamino)-5-fluoro-N-methylbenzamide were reacted according to the procedure of example 3.40 to afford 2-(5-chloro-2-(1,3-dimethyl-1H-pyrazol-4-ylamino)pyridin-4-ylamino)-5-fluoro-N-methylbenzamide (16.1 mg) as a beige solid. 1H NMR spectrum: (300 MHz, DMSO) δ 2.06 (3H, s), 2.77 (3H, d), 3.69 (3H, s), 6.60 (1H, s), 7.40 (1H, m), 7.55 (2H, m), 7.81 (1H, s), 7.93 (1H, s), 8.01 (1H, s), 8.72 (1H, m), 9.70 (1H, s); Mass spectrum: m/z (ESI+) (M+H)+ =389