tert-Butyl 3-methyl-4-nitro-1H-pyrazole-1-carboxylate → tert-Butyl 4-amino-3-methyl-1H-pyrazole-1-carboxylate

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Reaction Steps

tert-Butyl 3-methyl-4-nitropyrazole-1-carboxylate (815 mg) was dissolved in MeOH (20 ml) and hydrogenated at room temperature for 40 hours with 10% Pd/C (0.2 g, 50% wet). The catalyst was filtered off and the solvent removed in vacuo. Column chromatography on silica (4 g), eluting with 1:1 EtOAc-heptane (500 ml) gave tert-butyl 4-amino-3-methylpyrazole-1-carboxylate (400 mg).

Provenance & Evidence