HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1045997Generated: October 30, 2026
Ethyl orthoformate → 6-Chloropyrido[3,2-d]pyrimidin-4(3H)-one
https://huagongshe.com/reaction/1045997
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl orthoformate | HCID 31214 | — |
| Reactant | 3-Amino-6-chloropyridine-2-carboxamide | HCID 10749704 | — |
| Product | 6-Chloropyrido[3,2-d]pyrimidin-4(3H)-one | HCID 135427096 | — |
Reaction Steps
3-amino-6-chloro-pyridine-2-carboxylic acid amide (7.45 g, 43.41 mmol) is taken up in triethylorthoformate (150 mL) and stirred for 3 h at 145° C. After cooling the precipitate formed is filtered off, washed with Et2O, dried and 6-chloro-3H-pyrido[3,2-d]pyrimidin-4-one (HPLC-MS: tRet=0 min; MS (M+H)+=182) is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08569316B2 |
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| Source dataset | uspto-grants-2013_10 |
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| ORD ID | ord-81a5e221ad984bde9318edb7564dd633 |
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| Source note | uspto-grants-2013_10 |
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