HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → Lamivudine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Lamivudine oxalate | HCID 86677229 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | Lamivudine | HCID 60825 | — |
Reaction Steps
Specifically, Lamivudine oxalate is added to ethanol, and an amount of triethylamine is added thereto at the temperature of 40˜45° C. for 0.5 hr, and stirred for 4 h at the same temperature. The mixture is centrifuged at room temperature, and a product is dried under vacuum at the temperature of 40˜45° C. to obtain Lamivudine crystal.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08569322B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-eb7e2ad85efd4d20b3416678baf39123 |
| Source note | uspto-grants-2013_10 |