Cyclopropylamine → HCID 67019772, compound

Participants

Reaction Steps

The title compound was prepared from (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-ethyl)-1,3-oxazinan-2-one and methyl 6-chloropyridazine-3-carboxylate following procedures analogous to those described in Example 8 using cyclopropylamine in Step 2. LC-MS Method 2 tR=1.221 min, m/z=457.1; 1H NMR (CDCl3) 0.67 (m, 2H), 0.88 (m, 2H), 1.20 (s, 3H), 1.23 (s, 3H), 1.54 (d, 3H), 2.20 (m, 4H), 2.3 (s, 1H), 2.9 (m, 1H), 3.0 (m, 2H), 5.7 (m, 1H), 7.0 (m, 2H), 7.28-7.34 (m, 5H), 7.8 (m, 2H), 7.90 (m, 1H), 8.2 (m, 1H), 8.3 (m, 1H)

Provenance & Evidence