(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one → N-cyclopropyl-5-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)pyrimidine-2-carboxamide

Participants

Reaction Steps

The title compound was prepared from (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-ethyl)-1,3-oxazinan-2-one and 5-bromo-N-cyclopropylpyrimidine-2-carboxamide following a procedure analogous to that described in Example 1 Step 2. LC-MS Method 2 tR=1.167 min, m/z=515.2; 1H NMR (CDCl3) 0.65 (m, 2H), 0.87 (m, 2H), 1.09 (m, 6H), 1.51 (m, 3H), 2.26 (m, 2H), 2.31 (m, 2H), 2.43 (m, 3H), 2.83 (m, 1H), 2.98 (m, 1H), 5.67 (m, 1H), 7.06 (m, 1H), 7.25 (m, 7H), 8.02 (m, 1H), 8.89 (m, 2H)

Provenance & Evidence