2-Bromo-N-tert-butyl-1,3-thiazole-5-carboxamide → N-tert-butyl-2-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-2-oxo-6-phenyl-1,3-oxazinan-3-yl)ethyl)phenyl)thiazole-5-carboxamide

Participants

Reaction Steps

The title compound was prepared from (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one and 2-bromo-N-tert-butylthiazole-5-carboxamide following a procedure analogous to that described in Example 1 Step 2. LC-MS Method 2 tR=1.351 min, m/z=558.1; 1H NMR (CDCl3) 1.13 (s, 3H), 1.16 (s, 3H), 1.49 (s, 9H), 1.51 (d, 3H), 2.15-2.32 (m, 5H), 2.41 (m, 1H), 2.89 (m, 1H), 3.72 (m, 1H), 5.70 (m, 1H), 5.78 (m, 1H), 7.02 (m, 2H), 7.34 (m, 5H), 7.70 (m, 2H), 8.08 (m, 1H)

Provenance & Evidence