Water → HCID 58485290, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-bromo-2-chloropyrimidine (0.3 g, 1.55 mmol) in NMP (15 mL) were added 2,4-dimethyl-1H-imidazole (0.224 g, 2.2 mmol) and K2CO3 (0.43 g, 3.1 mmol). The resulting solution was stirred at 80° C. overnight. After water (50 mL) and EtOAc (50 mL) were added, the mixture was extracted with EtOAc (3×50 mL). The combined organic layer was washed with brine (50 mL), dried over Na2SO4, filtered, and concentrated. The residue was purified by pre-TLC to afford 5-bromo-2-(2,4-dimethyl-1H-imidazol-1-yl)-pyrimidine (0.2 g, 51%).

Provenance & Evidence