3-Pyridinylboronic acid → HCID 25183460, compound

HRID 1046105Notes

Reaction equation

HRID 1046105 reaction equation
Br[C:2]1[CH:3]=[C:4]([N:8]2[CH2:13][CH2:12][C:11]([CH3:20])([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:10][C:9]2=[O:21])[CH:5]=[CH:6][CH:7]=1.[N:22]1[CH:27]=[CH:26][CH:25]=[C:24](B(O)O)[CH:23]=1>>[CH3:20][C:11]1([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[O:10][C:9](=[O:21])[N:8]([C:4]2[CH:5]=[CH:6][CH:7]=[C:2]([C:24]3[CH:23]=[N:22][CH:27]=[CH:26][CH:25]=3)[CH:3]=2)[CH2:13][CH2:12]1

Participants

3

Reactant 2

HCID 27343783-Pyridinylboronic acidHCID 25183312HCID 25183312, compound

Product 1

HCID 25183460HCID 25183460, compound

Procedure

The title compound was prepared from 3-(3-bromophenyl)-6-methyl-6-phenyl-1,3-oxazinan-2-one and 3-pyridylboronic acid following procedures analogous to those in Example 1 Step 2. LC-MS Method 2, tR=1.819 min, m/z=345.1. 1H NMR (CDCl3) 1.80 (s, 3H), 2.45-2.65 (m, 2H), 3.40 (m, 1H), 3.62 (m, 1H), 7.30-7.60 (m, 8H), 7.85 (m, 1H), 8.40 (m, 1H), 8.75 (m, 1H), 9.00 (m, 1H), 9.30-9.50 (b, 2H).

Sources & evidence

ORD record
ord-89a117b815144ac8a28abf0a56c585a7
Source dataset
uspto-grants-2013_10
Patent number
US08569292B2

Reaction notes

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