(5-Fluoropyridin-3-yl)boronic acid → HCID 58109724, compound

Participants

Reaction Steps

The title compound was prepared from (R)-6-allyl-3-((S)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-1,3-oxazinan-2-one and 5-fluoropyridine-3-boronic acid following a procedure analogous to that described in Example 14. LC-MS Method 1 tR=1.84 min, m/z=435 (M+1); 1H NMR (CDCl3) 8.58 (t, 1H, J=1.5, 1.5 Hz), 8.44 (d, 1H, J=3 Hz), 7.51-7.48 (ddd, 1H, J=9, 4, 2 Hz), 7.33-7.262 (m, 4H), 7.04 (at, J=9, 9 Hz), 6.98 (d, 2H, 8 Hz), 5.76-5.66 (m, 2H), 5.11-5.00 (m, 2H), 3.00-2.95 (m, 1H), 2.65-2.5 (m, 2H), 2.41-2.33 (m, 1H) 2.31-2.18 (m, 2H), 1.55 (d, 3H, J=7 Hz).

Provenance & Evidence