2-Bromo-5-(trifluoromethyl)pyridine → (R)-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-3-((S)-1-(4-(5-(trifluoromethyl)pyridin-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one

Participants

Reaction Steps

The title compound was prepared from (R)-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one and 2-bromo-5-(trifluoromethyl)pyridine following a procedure analogous to that described in Example 14. LC-MS Method 1 tR=1.86, m/z=503 (M+1); 1H NMR (CDCl3) 8.87 (s, 1H), 7.93 (dd, 1H), 7.72 (t, 3H), 7.18 (m, 2H), 6.98 (m, 4H), 5.67 (m, 1H), 3.52 (t, 1H), 2.89 (m, 1H), 1.49 (d, 3H).

Provenance & Evidence