HRID1046225

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11735544

2-Bromo-4-cyanopyridine

C6H3BrN2

结构：C[C@@H](c1ccc(B2OC(C)(C)C(C)(C)O2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O

HCID59532385

(S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one

C28H38BNO5

PRODUCTS

生成物

结构：C[C@@H](c1ccc(-c2cc(C#N)ccn2)cc1)N1CC[C@](CC(C)(C)O)(c2ccccc2)OC1=O

HCID42605723

未命名化合物

PROCEDURE

实验过程

The title compound was prepared from (S)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one and 2-bromoisonicotinonitrile following a procedure analogous to that described in Example 138 Method 1. LC-MS Method 2 tR=1.419 min, m/z=478.1; 1H NMR (CD3OD) 0.93 (s, 3H), 1.26 (s, 3H), 1.57 (d, 3H), 2.17 (s, 2H), 2.25 (m, 1H), 2.41-2.58 (m, 2H), 3.06 (m, 1H), 5.58 (m, 1H), 7.08 (d, 2H), 7.25-7.40 (m, 5H), 7.59 (d, 1H), 7.80 (d, 2H), 8.10 (s, 1H), 8.29 (d, 1H).