3-Chloro-6-methylpyridazine → HCID 58109507, compound

HRID 1046228Notes

Reaction equation

HRID 1046228 reaction equation
[CH3:1][O:2][CH2:3][C@@:4]1([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[O:9][C:8](=[O:10])[N:7]([C@H:11]([C:13]2[CH:18]=[CH:17][C:16](B3OC(C)(C)C(C)(C)O3)=[CH:15][CH:14]=2)[CH3:12])[CH2:6][CH2:5]1.Cl[C:35]1[N:36]=[N:37][C:38]([CH3:41])=[CH:39][CH:40]=1>>[CH3:1][O:2][CH2:3][C@@:4]1([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[O:9][C:8](=[O:10])[N:7]([C@H:11]([C:13]2[CH:14]=[CH:15][C:16]([C:35]3[N:36]=[N:37][C:38]([CH3:41])=[CH:39][CH:40]=3)=[CH:17][CH:18]=2)[CH3:12])[CH2:6][CH2:5]1

Participants

3

Reactant 2

HCID 2272543-Chloro-6-methylpyridazineHCID 58109551HCID 58109551, compound

Product 1

HCID 58109507HCID 58109507, compound

Procedure

The title compound was prepared from (R)-6-(methoxymethyl)-6-phenyl-3-((S)-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)ethyl)-1,3-oxazinan-2-one and 3-chloro-6-methylpyridazine following a procedure analogous to that described in Example 14. Mass spectrum (ESI+): m/z=418 [M+H]+.

Sources & evidence

ORD record
ord-9cda9606d21f4cedbb238ca6490ea5b5
Source dataset
uspto-grants-2013_10
Patent number
US08569292B2

Reaction notes

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