4,5-Dimethylthiazole → HCID 67019831, compound

HRID 1046241Notes

Reaction equation

HRID 1046241 reaction equation
Br[C:2]1[CH:7]=[CH:6][C:5]([C@@H:8]([N:10]2[CH2:15][CH2:14][C@:13]([CH2:22][C:23]([OH:26])([CH3:25])[CH3:24])([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[O:12][C:11]2=[O:27])[CH3:9])=[CH:4][CH:3]=1.[CH3:28][C:29]1[N:30]=[CH:31][S:32][C:33]=1[CH3:34]>>[CH3:28][C:29]1[N:30]=[C:31]([C:2]2[CH:7]=[CH:6][C:5]([CH:8]([N:10]3[CH2:15][CH2:14][C@:13]([CH2:22][C:23]([OH:26])([CH3:24])[CH3:25])([C:16]4[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=4)[O:12][C:11]3=[O:27])[CH3:9])=[CH:4][CH:3]=2)[S:32][C:33]=1[CH3:34]

Participants

3

Reactant 2

HCID 625104,5-DimethylthiazoleHCID 44599033(S)-3-((S)-1-(4-bromophenyl)ethyl)-6-(2-hydroxy-2-methylpropyl)-6-phenyl-1,3-oxazinan-2-one

Product 1

HCID 67019831HCID 67019831, compound

Procedure

The title compound was prepared from 3-[(S)-1-(4-bromo-phenyl)-ethyl]-(S)-6-(2-hydroxy-2-methyl-propyl)-6-phenyl-[1,3]oxazinan-2-one and 4,5-dimethyl-thiazole following a procedure analogous to that described in Example 180. Mass spectrum (ESI+): m/z=465 [M+H]+.

Sources & evidence

ORD record
ord-0d423f72a3bb401fad1c78bc092e3115
Source dataset
uspto-grants-2013_10
Patent number
US08569292B2

Reaction notes

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