Cyclopropylamine → HCID 67019805, compound

HRID 1046257Notes

Reaction equation

[OH:1][C:2]([CH3:32])([CH3:31])[CH2:3][C@@:4]1([CH:28]([CH3:30])[CH3:29])[O:9][C:8](=[O:10])[N:7]([C@H:11]([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[CH:20]=[N:21][C:22]([C:25](O)=[O:26])=[N:23][CH:24]=3)=[CH:15][CH:14]=2)[CH3:12])[CH2:6][CH2:5]1.[CH:33]1([NH2:36])[CH2:35][CH2:34]1>>[CH:33]1([NH:36][C:25]([C:22]2[N:21]=[CH:20][C:19]([C:16]3[CH:17]=[CH:18][C:13]([C@@H:11]([N:7]4[CH2:6][CH2:5][C@:4]([CH2:3][C:2]([OH:1])([CH3:32])[CH3:31])([CH:28]([CH3:29])[CH3:30])[O:9][C:8]4=[O:10])[CH3:12])=[CH:14][CH:15]=3)=[CH:24][N:23]=2)=[O:26])[CH2:35][CH2:34]1

Participants

Reactant 2

HCID 69828Cyclopropylamine

HCID 67019793HCID 67019793, compound

Product 1

HCID 67019805HCID 67019805, compound

Procedure

The title compound was prepared from 5-(4-((S)-1-((S)-6-(2-hydroxy-2-methylpropyl)-6-isopropyl-2-oxo-1,3-oxazinan-3-yl)ethyl)phenyl)pyrimidine-2-carboxylic acid and cyclopropylamine following a procedure analogous to that described in Example 25 Step 7.

Sources & evidence

ORD record: ord-bef1f71d84814173873e5ed87b92c888
Source dataset: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08569292B2

Reaction notes

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