反应详情

温度

60 °C

To a solution of 140 mg (0.365 mmol) (2-benzylamino-5-propargyloxy-phenyl)-(4-isopropyl-phenyl)-methanone in 5 ml acetic acid is added 68 mg (0.695 mmol) potassium thiocyanate. The reaction is stirred for two days at 60° C. The solvent is removed and the residue is extracted with water/dichloromethane. After evaporation of the organic phase the crude product is purified by flash-chromatography (MeOH/CH2Cl2, 1:9) to give 25 mg (16%) of a yellow oil.

1. customThe solvent is removed
2. extractionthe residue is extracted with water/dichloromethane
3. customAfter evaporation of the organic phase the crude product
4. customis purified by flash-chromatography (MeOH/CH2Cl2, 1:9)