HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bicarbonate Ion → (2-Amino-4-hydroxy-5-methoxy-phenyl)-(4-isopropyl-phenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bicarbonate Ion | HCID 769 | — |
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Sodium ethanethiolate | HCID 4459711 | — |
| Reactant | (2-Amino-4,5-dimethoxy-phenyl)-(4-isopropyl-phenyl)-methanone | HCID 59259172 | — |
| Solvent | Water | HCID 962 | — |
| Product | (2-Amino-4-hydroxy-5-methoxy-phenyl)-(4-isopropyl-phenyl)-methanone | HCID 59259050 | — |
Reaction Steps
A mixture of 1.34 g (4.48 mmol) (2-amino-4,5-dimethoxy-phenyl)-(4-isopropyl-phenyl)-methanone, 1.88 g sodium ethanethiolate and 10 ml DMF are heated for 5 h to 110° C. Saturated aqueous bicarbonate solution (10 ml) and 100 ml water are added. The product is extracted with CH2Cl2 and chromatographed on silica (hexane/ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08569317B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-a3af2a98908d4032913ad8256a402946 |
| Source note | uspto-grants-2013_10 |