HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl Bromide → HCID 59259208, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl Bromide | HCID 7498 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | HCID 59259147 | HCID 59259147 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 59259208 | HCID 59259208 | — |
Reaction Steps
To a solution of 100 mg (299 μmol) 4-(4-isopropyl-phenyl)-6-prop-2-ynyloxy-1H-quinazoline-2-thione in 2 ml THF are added 35.5 μl (299 μmol) benzyl bromide and 76 μl (448 μmol) DIEA. After stirring for 18 h at r.t. the reaction mixture is extracted with dichloromethane and water. After evaporation of the organic layers the crude product is purified by flash chromatography using hexanes/ethyl acetate 20:1 as eluent.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08569317B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-dc59ced4f96b4d1d8bfccf53ec7b1323 |
| Source note | uspto-grants-2013_10 |