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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1046407Generated: October 31, 2026

Acetonitrile → HCID 178442401, compound

https://huagongshe.com/reaction/1046407

Reaction equation

Participants

RoleNameHCIDCharge
ReactantAcetonitrileHCID 6342—
ReactantTrifluoroacetic acidHCID 6422—
Reactant3-FluoropyridineHCID 67794—
ReactantHCID 178425834HCID 178425834—
SolventWaterHCID 962—
ProductHCID 178442401HCID 178442401—

Reaction Steps

The title compound was synthesized in a manner analogous to Example 1, using 5-(3,3-dimethyl-but-1-ynyl)-3-[(cis-3-hydroxy-cyclobutyl)-(4-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid in place of 5-(3,3-Dimethyl-but-1-ynyl)-3-[(trans-4-hydroxy-cyclohexyl)-(trans-4-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid and 3-fluoro-pyridine in place of 2-fluoro-pyridine: MS (m/z): 492.8 [M−H]−; HPLC retention time: 3.44 min (2-98% acetonitrile:water with 0.05% trifluoroacetic acid).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08569302B2
Source datasetuspto-grants-2013_10
ORD IDord-538a23173e9846c4a9bcca0cf938d624
Source noteuspto-grants-2013_10