Sodium Acetate → HCID 178461720, compound

Participants

Reaction Steps

A mixture of 3-[[3-(6-chloro-pyridazin-3-yloxy)-1(S)-methyl-propyl]-(trans-4-methyl-cyclohexanecarbonyl)-amino]-5-(3,3-dimethyl-but-1-ynyl)-thiophene-2-carboxylic acid TFA salt (0.56 g, 0.087 mmol) in AcOH (2.0 mL) and NaOAc (0.37 g, 0.434 mmol) was placed in a preheated 100° C. oil bath and stirred for 3 h. The reaction was determined to be complete by LC/MS. After cooling, the reaction was diluted with CH3OH (5 mL). 5-(3,3-Dimethyl-but-1-ynyl)-3-[[3-(6-hydroxy-pyridazin-3-yloxy)-1-(S)-methyl-propyl]-(trans-4-methyl-cyclohexanecarbonyl)-amino]-thiophene-2-carboxylic acid TFA salt (0.07 g, 13%) was isolated by reverse phase HPLC as an off-white solid.

Provenance & Evidence