Isopropyl iodide → HCID 66828962, compound

Participants

Reaction Steps

A mixture of 1-isopropyl-4-(4-methoxy-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)-1H-pyrrole-2-carboxylic acid (200 mg, 0.37 mmol), 2-iodopropane (310 mg, 1.80 mmol), Cs2CO3 (360 mg, 1.1 mmol) in THF (50 mL) was stirred at reflux for 6 hours. After cooling down, ethyl acetate (100 mL) and water (50 mL) were added. The organic layer was separated and washed by water (30 mL) and brine, dried over anhydrous Na2SO4, filtered and concentrated in vacuo to give the title compound as a yellowish oil (100 mg).

Provenance & Evidence