HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1046490Generated: October 30, 2026
Dimethylamine, hydrochloride → HCID 66829143, compound
https://huagongshe.com/reaction/1046490
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylamine, hydrochloride | HCID 10473 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 66825690 | HCID 66825690 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | HCID 66829143 | HCID 66829143 | 68% |
Reaction Steps
A mixture of 4-(4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridin-3-yl)picolinic acid (100 mg, 0.17 mmole), dimethylamine hydrochloride (30 mg, 0.34 mmole), HATU (100 mg, 0.26 mole), DIPEA (0.2 mL) in DMF (20 mL) was stirred overnight at 25° C. Ethyl acetate (100 mL) and water (50 mL) were added. The organic layer was separated and washed with water (30 mL) and brine, dried over anhydrous Na2SO4, filtered and concentrated in vacuo to give the crude desired product as a yellowish oil (70 mg, 68%). LCMS (Method A): m/z=610 [M+H]+; 2.33 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08569281B2 |
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| Source dataset | uspto-grants-2013_10 |
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| ORD ID | ord-cb90b20fdd2f444984ac2fd9f31ea17b |
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| Source note | uspto-grants-2013_10 |
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