Bromomethylcyclopropane → HCID 66828854, compound

Participants

Reaction Steps

Prepared according to the general procedure described in Example 86, by reacting 4-methoxy-3-(1H-pyrazol-4-yl)-1-trityl-1H-pyrazolo[4,3-c]pyridine with cyclopropylmethyl bromide to give the title compound (21.3 mg, 45% over two steps). LC-MS (Method G): m/z=270.0 [M+H]+; 3.41 min. 1H-NMR (400 MHz, DMSO): δ 13.25 (s, 1H), 8.33 (s, 1H), 7.99 (s, 1H), 7.85 (d, J=5.7, 1H), 7.08 (d, J=5.9, 1H), 4.09-4.03 (m, 5H), 1.37-1.24 (m, 1H), 0.63-0.54 (m, 2H), 0.46-0.39 (m, 2H).

Provenance & Evidence