Oxetan-3-amine hydrochloride → N-(Oxetan-3-yl)-4-(4-(tetrahydro-2H-pyran-4-yloxy)-1H-pyrazolo[4,3-c]pyridin-3-yl)pyridin-2-amine

Participants

Reaction Steps

Prepared according to the procedure described in Example 111, by reacting 3-(2-chloropyridin-4-yl)-4-(tetrahydro-2H-pyran-4-yloxy)-1-trityl-1H-pyrazolo[4,3-c]pyridine with 3-aminooxetane hydrochloride for 70 minutes in Step 1 to give the title compound (13.3 mg, 19% over two steps). LC-MS (Method G): m/z=368.1 [M+H]+; 2.93 min. 1H-NMR (400 MHz, DMSO): δ 13.68 (s, 1H), 8.24 (d, J=7.1, 1H), 7.96-7.91 (m, 1H), 7.63 (s, 1H), 7.54 (d, J=7.1, 1H), 7.24 (d, J=5.4, 1H), 5.55-5.40 (m, 2H), 3.91-3.81 (m, 2H), 3.68-3.46 (m, 5H), 2.18-1.99 (m, 2H), 1.91-1.78 (m, 2H).

Provenance & Evidence