Trifluoromethanesulfonic acid → HCID 66825680, compound

Participants

Reaction Steps

The crude 1-(4-methoxybenzyl)-3-phenoxy-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[4,3-c]pyridin-4-amine from step 1 was added to methylene chloride (5 mL) and trifluoromethanesulfonic acid (0.5 mL), and the resulting mixture was stirred at room temperature for two hours. The mixture was concentrated under reduced pressure and the residue was purified by reverse phase HPLC to give 3-phenoxy-N-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[4,3-c]pyridin-4-amine: LC-MS (Method G): m/z=311.1; 1H NMR (400 MHz, DMSO): δ 12.43 (s, 1H), 7.73 (d, J=6.1, 1H), 7.42 (t, J=7.9, 2H), 7.26 (d, J=8.0, 2H), 7.19 (t, J=7.3, 1H), 6.60 (d, J=6.1, 1H), 5.43 (d, J=7.7, 1H), 4.19 (m, 1H), 3.79 (d, J=11.6, 2H, 1.83 (d, J=12.4, 2H), 1.43 (m, 2H).

Provenance & Evidence