HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 54680213, compound → HCID 66757441, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 54680213 | HCID 54680213 | — |
| Reactant | HCID 66757266 | HCID 66757266 | — |
| Product | HCID 66757441 | HCID 66757441 | — |
Reaction Steps
Referring to Scheme 4, methoxybenzothiophene ester 1, for example, is converted to the corresponding hydroxybenzothiophene carboxylic acid 2 with boron tribromide. Carboxylic acid 2 is coupled with Hca amine to yield hydroxybenzothiophene amide 3. 1-Substituted 4-hydroxypiperidine 4 is coupled with amide 3 to yield (piperidin-4-yloxy)benzothiopheneamide 5.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08569340B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-12080a43cc4649868324236978bea3f0 |
| Source note | uspto-grants-2013_10 |