HCID 46896668, compound → HCID 66616560, compound

Participants

Reaction Steps

A mixture of 4-[4-(8-benzyloxy-imidazo[1,2-a]pyridine-3-yl)-pyrimidin-2-ylamino]-cyclohexanecarboxylic acid ethyl ester (0.215 g) and Pd/C (10%, 600 mg) in EtOH (200 mL) was stirred under H2 overnight. The reaction mixture was heated and filtered hot through silica. The product was washed with DCM, and the filtrate concentrated and dried to provide 4-[4-(8-hydroxy-imidazo[1,2-a]pyridine-3-yl)-pyrimidin-2-ylamino]-cyclohexanecarboxylic acid ethyl ester (128 mg), which was used without further purification.

Provenance & Evidence