Piperidin-4-ol → HCID 46896573, compound

Participants

Reaction Steps

A mixture of 4-[4-(8-benzyloxy-imidazo[1,2-a]pyridine-3-yl)-pyrimidin-2-ylamino]-cyclohexanecarboxylic acid ethyl ester (0.23 g) in DMF (10 mL) was treated with BOP (79 mg), then DIEA (0.345 g), then piperidin-4-ol (79 mg), and the mixture stirred at RT for 5 h. The reaction mixture was then diluted with water, and the resulting solid filtered, washed with water, and dried. The solid was then dissolved in hot EtOAc, MeOH, and DCM, and the solution filtered hot. The product was dried at 50° C. under vacuum overnight to provide {4-[4-(8-benzyloxy-imidazo[1,2-a]pyridin-3-yl)-pyrimidin-2-ylamino]-cyclohexyl}-(4-hydroxy-piperidin-1-yl)-methanone (compound 6, 244 mg).

Provenance & Evidence