HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → HCID 86624364, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Tert-butyl 4'-bromomethyl-3'-fluoro-biphenyl-2-carboxylate | HCID 53375348 | — |
| Reactant | HCID 178467429 | HCID 178467429 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 86624364 | HCID 86624364 | 76.7% |
Reaction Steps
A solution of 4-chloro-2-ethoxyimidazole-5-carboxaldehyde (295.0 mg, 1.7 mmol), 4′-bromomethyl-3′-fluorobiphenyl-2-carboxylic acid t-butyl ester (617 mg, 1.7 mmol) and potassium carbonate (467 mg, 3.4 mmol) in DMF (6 mL) was stirred overnight. The mixture was filtered and concentrated in vacuo. Silica gel chromatography (hexane:EtOAc) afforded intermediate (27a) (598 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08569351B2 |
| Source dataset | uspto-grants-2013_10 |
| ORD ID | ord-680dba80618142d98fa54abb0146e538 |
| Source note | uspto-grants-2013_10 |