HRID1046715

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID944

Nitric Acid

HNO3

HCID9750

Citrulline

C6H13N3O3

结构：NC(=O)NCCC[C@H](N)C(=O)O.O=[N+]([O-])O

HCID86628843

未命名化合物

PRODUCTS

生成物

结构：NC(=O)NCCC[C@H](N)C(=O)O.O=[N+]([O-])O.O=[N+]([O-])O

HCID86628841

未命名化合物

结构：NC(=O)NCCC[C@H](N)C(=O)O.O=[N+]([O-])O.O=[N+]([O-])O.O=[N+]([O-])O

HCID86628842

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Applicants have cost-effectively synthesized Citrulline Nitrate by combining nitric acid and Citrulline, mixing with water, and leaving to crystallize. Further nitratization can take place, yielding Citrulline Dinitrate or Citrulline Trinitrate. An alternative implementation may comprise using Nitrous Acid (HNO2) instead of Nitric Acid (HNO3), thus yielding Citrulline Nitrite. Citrulline Nitrite has the same effects as Citrulline Nitrate, the only difference being that it requires one less step to yield Nitric Oxide (NO—). Mixed salts may also be used, such as in the non-limiting example of Citrulline Nitrate-Orotate.

WORKUP

后处理

customleaving
customto crystallize

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ccefffc0915e48e9b0e6cce0a54cf6af
来源数据集: uspto-grants-2013_10
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08569369B2
来源说明: uspto-grants-2013_10

反应 SMILES

[N+:1]([O-:4])([OH:3])=[O:2].[NH2:5][C@H:6]([C:14]([OH:16])=[O:15])[CH2:7][CH2:8][CH2:9][NH:10][C:11]([NH2:13])=[O:12].[N+:17]([O-:20])([OH:19])=[O:18].[NH2:21][C@H:22]([C:30]([OH:32])=[O:31])[CH2:23][CH2:24][CH2:25][NH:26][C:27]([NH2:29])=[O:28]>O>[N+:1]([O-:4])([OH:3])=[O:2].[N+:17]([O-:20])([OH:19])=[O:18].[NH2:5][C@H:6]([C:14]([OH:16])=[O:15])[CH2:7][CH2:8][CH2:9][NH:10][C:11]([NH2:13])=[O:12].[N+:1]([O-:4])([OH:3])=[O:2].[N+:1]([O-:4])([OH:3])=[O:2].[N+:1]([O-:4])([OH:3])=[O:2].[NH2:21][C@H:22]([C:30]([OH:32])=[O:31])[CH2:23][CH2:24][CH2:25][NH:26][C:27]([NH2:29])=[O:28]