Ethanolamine → HCID 59758716, compound

HRID 1046733Notes

Reaction equation

HRID 1046733 reaction equation
[NH2:1][CH2:2][CH2:3][OH:4].[CH3:5][Si:6]([CH3:21])([CH2:15][CH2:16][Si:17]([CH3:20])([CH3:19])[CH3:18])[CH2:7][CH2:8][CH2:9][O:10][CH2:11][CH:12]1[CH2:14][O:13]1>C(O)C>[CH3:5][Si:6]([CH3:21])([CH2:15][CH2:16][Si:17]([CH3:20])([CH3:19])[CH3:18])[CH2:7][CH2:8][CH2:9][O:10][CH2:11][CH:12]([OH:13])[CH2:14][NH:1][CH2:2][CH2:3][OH:4]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 597587042-{3-[Dimethyl-(2-trimethylsilanyl-ethyl)-silanyl]-propoxymethyl}-oxirane

Product 1

HCID 59758716HCID 59758716, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent3×

Conditions

Temperature
70 °C

Procedure

2-Amino-ethanol (2.22 g; 36.4 mMol) and 40 mL of ethanol were charged to a 100 mL RB flask equipped with a magnetic stirrer. The mixture was stirred and heated to 70° C. 2-{3-[Dimethyl-(2-trimethylsilanyl-ethyl)-silanyl]-propoxymethyl}-oxirane 8 (2 g; 7.28 mMol) mixed with 10 g ethanol was placed in an addition funnel and added dropwise to the flask. The mixture was stirred and maintained at 70° C. for an additional 4 hours. Ethanol was stripped off on the rotovap. The mixture was distilled under vacuum to remove impurities and excess 2-amino-ethanol.

Workup

  1. customequipped with a magnetic stirrer
  2. customwas placed in an addition funnel
  3. additionadded dropwise to the flask
  4. stirringThe mixture was stirred
  5. temperaturemaintained at 70° C. for an additional 4 hours
  6. distillationThe mixture was distilled under vacuum
  7. customto remove impurities and excess 2-amino-ethanol

Sources & evidence

ORD record
ord-ac27948a9d5642e59176049e1647026f
Source dataset
uspto-grants-2013_10
Patent number
US08569385B2

Reaction notes

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