3-Methoxybenzenethiol → 3-(2-Fluoro-3-aminobenzyl)-7-methyloxy-4-methyl-2-oxo-2H-1-benzothiopyran
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([SH:9])[CH:6]=[CH:7][CH:8]=1.C([O:12][C:13](=O)[CH:14]([CH2:18][C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([NH2:25])[C:20]=1[F:26])[C:15](=O)[CH3:16])C>>[F:26][C:20]1[C:21]([NH2:25])=[CH:22][CH:23]=[CH:24][C:19]=1[CH2:18][C:14]1[C:13](=[O:12])[S:9][C:5]2[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=[CH:7][C:6]=2[C:15]=1[CH3:16]Participants
3
Procedure
The title compound was synthesized using 3-methyloxy-benzenethiol and 2-(2-fluoro-3-aminobenzyl)-3-oxobutanoic acid ethyl ester under the same conditions as in the manufacturing example for compound 5d-0-4S1.
Sources & evidence
- ORD record
- ord-a9ce7fad2abb47d381d1cf196a5f6d19
- Source dataset
- uspto-grants-2013_10
- Patent number
- US08569378B2
Reaction notes
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