1,4-Dioxane hydrochloride → HCID 67503064, compound

Participants

Reaction Steps

tert-Butyl[1-(4-{2-[4-(pyrrolidin-1-ylcarbonyl)phenyl]-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl}phenyl)cyclobutyl]carbamate (12 mg, 0.018 mmol) in MeOH (0.5 mL) was added 4N HCl-dioxane (2 mL) and stirred at r.t for 12 hours. The mixture was concentrated to afford the desired product (12 mg, quant) as a yellow solid. 1HNMR (DMSO-d6) 400 MHz δ: 8.62 (s, 1H), 8.60 (br s, 2H), 8.11 (dd, J=4.6 Hz and 1.7 Hz, 1H), 7.97 (dd, J=8.0 Hz and 1.7 Hz, 1H), 7.53 (t, J=8.0 Hz, 4H), 7.45 (d, J=8.6 Hz, 2H), 7.39-7.34 (m, 3H), 7.30 (d, J=7.4 Hz, 1H), 7.13 (td, J=8.6 Hz and 1.1 Hz, 1H), 6.90 (dd, J=8.0 Hz and 1.7 Hz, 1H), 6.74 (dd, J=8.0 Hz and 4.6 Hz, 1H), 3.73-3.65 (m, 1H), 2.61-2.53 (m, 6H), 2.23-2.14 (m, 1H), 1.89-1.78 (m, 6H). LCMS: 553 [M+H].

Provenance & Evidence