1,4-Dioxane hydrochloride → HCID 67504334, compound

Participants

Reaction Steps

Methyl 4-[3-(4-{1-[(tert-butoxycarbonyl)amino]cyclobutyl}phenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-2-yl]-2-hydroxybenzoate (33 mg, 0.052 mmol) in MeOH (0.5 mL) was added 4N HCl-dioxane (2 mL) and stirred at room temperature for 13 hours. The mixture was concentrated to afford the desired product (30 mg, 90%) as a yellow solid. 1HNMR (DMSO-d6) 400 MHz δ: 10.48 (s, 1H), 8.64-8.62 (m, 3H), 8.10 (dd, J=4.9 Hz and 1.4 Hz, 1H), 7.96 (dd, J=8.0 Hz and 1.4 Hz, 1H), 7.69 (d, J=8.0 Hz, 1H), 7.57 (d, J=8.0 Hz, 1H), 7.39-7.36 (m, 2H), 7.30 (dd, J=8.0 Hz and 1.1 Hz, 1H), 7.15-7.06 (m, 2H), 6.89 (dd, J=8.0 Hz and 1.1 Hz, 1H), 6.73 (dd, J=8.0 Hz and 4.6 Hz, 1H), 3.88 (s, 3H), 3.51-3.45 (m, 2H), 2.64-2.52 (m, 2H), 2.23-2.15 (m, 1H), 1.88-1.81 (m, 1H). LCMS: 530 [M+H].

Provenance & Evidence