1,4-Dioxane hydrochloride → HCID 67503660, compound

Participants

Reaction Steps

tert-Butyl {1-[4-(2-{3-[(methylsulfonyl)amino]phenyl}-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl)phenyl]cyclobutyl}carbamate (13.7 mg, 0.0211 mmol) was dissolved in DCM (1 mL). 4M HCl/dioxane (1 mL) was added to the mixture and stirred at room temperature for 11.5 hours. The mixture was concentrated and solidified with ether. The precipitated solids were collected by filtration and washed with ether to afford desired product (12.5 mg, 89.7%) as pale yellow solid. 1HNMR (DMSO-d6) 400 MHz δ: 9.76 (s, 1H), 8.67 (br s, 2H), 8.62 (s, 1H), 8.10 (dd, J=4.6, 1.4 Hz, 1H), 7.94 (dd, J=7.6, 1.6 Hz, 1H), 7.53 (d, J=8.7 Hz, 2H), 7.49-7.47 (m, 1H), 7.41-7.29 (m, 4H), 7.25 (t, J=7.8 Hz, 1H), 7.19-7.08 (m, 3H), 6.88 (dd, J=7.8, 1.4 Hz, 1H), 6.73 (dd, J=8.0, 4.6 Hz, 1H), 2.90 (s, 3H), 2.61-2.48 (m, 4H), 2.25-2.12 (m, 1H), 1.89-1.76 (m, 1H).

Provenance & Evidence