1,4-Dioxane hydrochloride → HCID 67503754, compound

Participants

Reaction Steps

tert-Butyl (1-{4-[2-(4-hydroxyphenyl)-9H-imidazo[1,2-d]pyrido[2,3-b][1,4]benzodiazepin-3-yl]phenyl}cyclobutyl)carbamate (34 mg, 0.060 mmol) in MeOH (0.5 mL) was added 4N HCl-dioxane (2 mL) and stirred at room temperature for 34 hours. The mixture was concentrated to afford the desired product (33 mg, 96%) as a brown solid. 1HNMR (DMSO-d6) 400 MHz δ: 8.71-8.67 (m, 3H), 8.13 (dd, J=4.6, 1.4 Hz, 1H), 7.94 (dd, J=8.0, 1.4 Hz, 1H), 7.53 (d, J=9.7 Hz, 2H), 7.41 (t, J=7.7 Hz, 1H), 7.32-7.28 (m, 4H), 7.15 (t, J=7.4 Hz, 1H), 6.89 (dd, J=8.6, 1.7 Hz, 1H), 6.76 (dd, J=8.6, 4.6 Hz, 1H), 6.72 (d, J=8.6 Hz, 1H), 3.73-3.65 (m, 1H), 3.51-3.45 (m, 1H), 2.60-2.53 (m, 2H), 2.23-2.14 (m, 1H), 1.86-1.78 (m, 1H). LCMS: 472 [M+H].

Provenance & Evidence